One Platform. Multiple Critical Bioprocess Measurements
POWERED BY LOW-FIELD NMR, CHROMWATCH DELIVERS RAPID, ACCURATE, MULTI-ATTRIBUTE AT-LINE MEASUREMENTS, HELPING BIOPHARMACEUTICAL MANUFACTURERS IMPROVE PROCESS UNDERSTANDING AND EFFICIENCY.
VISION
Transforming Bioprocessing Through Multi-Attribute Analysis
Critical bioprocess measurements are often fragmented across multiple instruments, workflows and analytical methods, introducing delays, variability and unnecessary complexity.
ChromWatch is changing that.
Our multi-attribute PAT platform uses low-field nuclear magnetic resonance (LF-NMR) to support rapid, direct analysis of critical process attributes through a single analytical platform.
From buffer preparation and viral inactivation to downstream purification and formulation, we aim to help manufacturers unlock greater process visibility, improve efficiency and reduce dependence on time-consuming offline analysis.
Product applications
One Platform. Multiple Applications
ChromWatch brings together a growing range of downstream bioprocess measurements within one analytical platform.
Established applications
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Viral Inactivation: Rapid pH determination and adjustment.
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Buffer Concentration: Accurate concentration measurement and verification.
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Conductivity & Ionic Salts: Concentration measurements to support downstream process control.
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Buffer Composition: Verification of individual buffer components.
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Excipients: Quantification of polysorbates, including PS80 in formulations containing monoclonal antibody proteins.
Additional applications being validated or developed
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Detergent Clearance: Analytical method development for quantifying viral inactivation detergents and supporting downstream clearance studies.
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Protein Concentration: Analytical method development for quantifying protein concentrations in downstream processing.
OUR PRODUCT
Rugged & Durable PAT, Uncompromisingly Accurate
REAL TIME pH AND CONCENTRATION DETERMINATION
±0.02 pH
Consistent Accuracy
2 Min
to Analyse and Calculate
ChromWatch BCS provides real-time buffer pH and concentration without user calibration or physical sample contact. Utilising proprietary algorithms designed to ensure consistent accuracy with no drift, it instantly calculates the precise acid or base volume needed for pH adjustments, such as in viral inactivation.
STREAMLINED - NO USER VARIANCE
21 CFR Part 11
Secure Records
Easy sample prep
1-2 mins
ChromWatch BCS provides fully streamlined, standardised sample preparation that eliminates user variability while remaining fully compatible with FDA 21 CFR Part 11 and EU Annex 11, supporting secure electronic records, audit trails, and compliant data management. Designed to integrate seamlessly into existing GMP workflows, it uses a proprietary analysis device that connects with standard process equipment and employs automated, guided workflows with intuitive software requiring minimal training to deliver consistent, reproducible results. ChromWatch BCS enhances compliance, data integrity, and process efficiency for modern biopharma applications.
ADVANCED SENSOR TECHNOLOGY
Low-Field NMR
Direct Measurement
No User Calibration
Auto-calibrates
Experience true precision with ChromWatch BCS — the only system offering direct measurement of pH and concentration. With no contact, no sensor fouling, and zero protein adhesion, you get reliable results every time. Say goodbye to calibration delays and sample contamination — and hello to faster, cleaner, more confident process control.
OUR PRODUCT
Rugged & Durable PAT, Uncompromisingly Accurate
WHY CHROMWATCH PA
More Process Insight.
Less Analytical Complexity.
Traditional analytical workflows often require different instruments, methods and specialist expertise for individual process measurements.
ChromWatch takes a different approach.
Our proprietary low-field NMR technology enables multiple analytical applications on a common platform, bringing simplicity and flexibility to downstream bioprocessing.
Key advantages:
- Multi-Attribute: A growing portfolio of critical process measurements on one platform.
- Rapid: Actionable analytical results in minutes, with measurement time dependent on the application.
- Simplified: No routine user calibration and standardised analytical workflows.
- Process-Ready: Designed for integration into regulated biopharmaceutical manufacturing environments.
COMPANY
ChromWatch PA in Numbers
247
Employees
5
Core Teams
326
Partners Worldwide
$200m
Capital
COLLABORATION
Our Industry Partners
